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ey0016.5-17 | Basic Science - Bone | ESPEYB16

5.17. Coupling of bone resorption and formation by RANKL reverse signalling

Y Ikebuchi , S Aoki , M Honma , M Hayashi , Y Sugamori , M Khan , Y Kariya , G Kato , Y Tabata , JM Penninger , N Udagawa , K Aoki , H Suzuki

Abstract: Nature. 2018 Sep;561(7722):195200.In brief: This study used various cell-based methods and animal models to investigate the RANK-RANKL signaling pathway in bone homeostasis. The authors show for the first time, that reverse signaling exists from osteoclast to osteoblast and that vesicular RANK, secreted by the osteoclast, relays information to the osteoblast...

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ey0016.9-5 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.5. Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus

R Nakagawa , A Hosokawa-Tsuji , Y Aoki , K Takasawa , M Maru , K Nakajima , A Sutani , Y Miyakawa , D Tomizawa , K Kashimada , T Morio

To read the full abstract: Endocrine. 2018 Jul; 61(1):76Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies. However, late HSCT adverse effects cause substantial morbidity among long-term survivors. Metabolic complications, such as diabetes mellitus and hyperlipidemia, are the major late effects of pediatric HSCT, but the pathogenesis ...

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ESPE Yearbook of Paediatric Endocrinology

5.17. Coupling of bone resorption and formation by RANKL reverse signalling

9.5. Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus

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